To unlock the following guitars and basses, fulfill the requirement listed. (Some basses and guitars must be purchased after the required fulfillment is met, while others are unlocked automatically).

• Axe (G) - Win Expert Career mode
• Casket (G) - Win Medium Career mode
• Cream SG (B) - Get five stars on any twenty songs in co-op mode
• Eyeball (G) - Get five stars on every song in Hard Career mode
• Fish (G) - Win Easy Career mode
• Gibson Grabber (B) - Finish any twenty songs in co-op mode
• Gibson SG (B) - Finish any ten songs in co-op mode
• Gibson Thunderbird (B) - Finish any thirty songs in co-op mode
• Hofner (B) - Finish every song in co-op mode
• Lava Pearl Musicman Stingray (B) - Get five stars on every song in co-op mode
• Natural Maple Gibson Grabber (B) - Get four stars on every song in co-op mode
• Natural Sunburst Gibson Thunderbird (B) - Get five stars on every song in co-op mode
• Snaketapus (G) - Win Hard Career mode
• The LOG (G) - Get five stars on every song in Expert Career mode
• USA (G) - Get five stars on every song in Easy Career mode
• Viking (G) - Get five stars on every song in Medium Career mode