Completed Welcome (10 points): Successfully complete the Welcome To Rapture Level
Maxed One Track (20 points): Purchased every slot in one of the Plasmid or Tonic tracks
Maxed All Tracks (50 points): Purchased every slot in all four Plasmid and Tonic tracks
Bought One Slot (5 points): Purchase one slot in any Plasmid or Tonic track
Upgraded a Weapon (5 points): Acquire at least one weapon upgrade
One Fully Upgraded Weapon (5 points): Fully upgrade one weapon
Two Fully Upgraded Weapons (5 points): Fully upgrade two weapons
Three Fully Upgraded Weapons (10 points): Fully upgrade three weapons
Four Fully Upgraded Weapons (10 points): Fully upgrade four weapons
Five Fully Upgraded Weapons (10 points): Fully upgrade five weapons
Weapon Specialist (20 points): Acquire all upgrades for all weapons
Fully Researched Thug Splicer (10 points): Fully research the Thuggish Splicer
Fully Researched Gun Splicer (10 points): Fully research the Leadhead Splicer
Fully Researched Spider Splicer (10 points): Fully research the Spider Splicer
Fully Researched Houdini Splicer (10 points): Fully research the Houdini Splicer
Fully Researched Nitro Splicer (10 points): Fully research the Nitro Splicer
Fully Researched Rosie (10 points): Fully research the Rosie
Fully Researched Bouncer (10 points): Fully research the Bouncer
Fully Researched Little Sister (10 points): Fully research the Little Sister
Prolific Photographer (5 points): Take at least one photo in every research group
Research PhD (20 points): Max out all possible research
Quality Research Photo (5 points): Take a Research Photo of the highest grade
Researched a Splicer (5 points): Take at least one Research Photo of a Splicer
One Successful Hack (5 points): Perform at least one successful hack
Hacked a Security Bot (10 points): Successfully hack a security bot
Hacked a Security Camera (10 points): Successfully hack a security camera
Hacked a Turret (10 points): Successfully hack a turret
Hacked a Vending Machine (10 points): Successfully hack a vending machine
Hacked a Safe (10 points): Successfully hack a safe
Skilled Hacker (40 points): Successfully complete 50 hacks
Basic Inventor (5 points): Successfully invent at least one item
Avid Inventor (10 points): Successfully invent at least 100 items
Ammo Inventor (25 points): Successfully invented all possible ammo types
Little Sister Savior (100 points): Complete the game without harvesting any Little Sisters
Tonic Collector (50 points): Collect or Invent 53 Tonics in the Physical, Engineering and Combat tracks
Historian (50 points): Find every audio diary
Seriously Good At This (40 points): Complete the game on the hardest difficulty setting
Dealt with every Little Sister (40 points): Either Harvest or Rescue every Little Sister in the game
Lucky Winner (10 points): Hit the jackpot at a slot machine
Toaster in the Tub (10 points): Shock an enemy in the water

Secret Achievements

Defeated Dr. Steinman (15 points): Defeat the crazed Dr. Steinman
Defeated Peach Wilkins (15 points): Defeat Peach Wilkins
Restored the Forest (15 points): Restore the forests of Arcadia
Completed Cohen's Masterpiece (30 points): Complete Sander Cohen's great masterpiece
Defeated Andrew Ryan (30 points): Defeat Andrew Ryan
Broke Fontaine's Mind Control (30 points): Break Fontaine's mind control
Defeated Atlas (100 points): Defeat Atlas
Became a Big Daddy (30 points): Become a Big Daddy
Irony (10 points): Take a picture of Sander Cohen's corpse
Found Cohen's Room (10 points): Enter Sander Cohen's personal quarters

Downloadable Content Achievement

Brass Balls (100 points): Complete the game on the Hard difficulty setting without dying (turn off the Vita Chambers)